Background: Plants have been reported to exhibit antioxidant activity, which protect against the damage caused by reactive oxygen species. Aim: To investigating the antioxidant activity of the methanolic extracts of Globimetula braunii in serum and tissues of hypercholesteremic albino rats. Settings and Design: Thirty male albino rats were used for the present investigation. They were divided into six groups of five animals. Method and Materials: Oxidative stress was induced in the rats by feeding with dietary cholesterol at a dose of 40mg/kg body weight. Antioxidant activities of the methanolic extracts of Globimetula braunii were studied in the tissues of the oxidative stressed rats. Statistical Analysis: Statistical significance of the difference between experimental groups was calculated using the Student’s t-test. Results: There was a significant increase (p<0.05) in the lipid peroxidation (LPO) of the Liver; a significant decrease (p>0.05) in kidney and Liver GSH level, and a significant increase (p<0.05) in kidney and liver Catalase activities in the cholesterol-fed rats. A significant decrease (p>0.05) in liver SOD activity was also observed, with no significant difference was observed in the serum ALT and AST activities. Globimetula braunii significantly (p<0.05) reduced LPO and GSH activity. There was a significant increase (p<0.05) in the activities of SOD and Catalase activities. Co-administration of Globimetula braunii with dietary cholesterol showed no significant effect on ALT and AST activities. Conclusion: A positive modulation in GSH, SOD and Catalase activities; and reduction in LPO by the methanolic extracts of Globimetula braunii under hypercholesteremia condition is an indication of its protective ability in the management of oxidative stress, and hypercholesteremia.
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